Paracetamol is an important drug in the category of analgesic & antipyretic used in treatment of acute pain, But yet many of us know little pharmacokinetics. The determination of pharmacokinetics of the drug is the determination of absorption, distribution, metabolism and excretion (ADME) time course of drug and how it is related to pharmacological activity of drug such as its therapeutic and toxic activity. The determination of drug concentration in saliva as an alternative body fluid for pharmacokinetic determination is widely accepted now days. It is mainly suitable for geriatric and pediatric patient as it can be collected easily with minimal patient discomfort and obtained on multiple occasions. The determination of drug concentration in saliva has been employed for therapeutic drug monitoring and measurement of various pharmacokinetic parameters, which can provide knowledge of patient-specific pharmacokinetic parameters leading to improved therapy. The present study was undertaken to evaluate the pharmacokinetics of model drug in saliva when administered in different media like water, milk, juice and to measure the concentration in the saliva in healthy volunteers.
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